(Part 1 of this 2 part series is here.)
As a possible antidote or balance for someone seeking ways ag-biotech might contribute to sustainable agriculture and food systems, I searched not the web, but local university library shelves, and located a 2012 edited volume that promised to fill out this more positive bill. In this essay collection, The Role of Biotechnology in a Sustainable Food Supply, eds. Jennie S. Popp, Milly M. Jahn, Marty D. Matlock, and Nathan P. Kemper (New York: Cambridge University Press, 2012), I sought updates and possible answers to the issues raised in The GMO Deception. Peggy Lemaux’s chapter, “Genetically Engineered Crops Can Be Part of a Sustainable Food Supply,” was the most likely candidate, but did not provide completely satisfactory responses. A multi-authored interdisciplinary project paper on Healthy Potatoes for Wisconsin was similarly discouraging on major issues, such as outlooks for social equity and renewable soils. From beginning to end, issues of equity, or shared prosperity, were also concerns.
Lemaux’s chapter was an update of her 2008 Ann. Rev. of Plant Biology 59:771-812 article: “Genetically Engineered Plants and Foods: A Scientist’s Analysis of the Issues. (Part I)” It briefly reviews and dismisses many of the safety questions raised in GeneWatch reports, which were collected in the edited “Deception” volume. Some of her analyses effectively blunt well-publicized anti-GMO concerns. For example, no food plants GE’d to express anti-freeze fish genes have ever been released or approved for human consumption. Lower nutrient contents found in some comparative studies of GE versus conventional food-plant varieties are within the normal range of variation found in conventional food-plant products. Higher than expected nutrient values that are purposely introduced by GE must be so labeled. There are many and more diverse food-safety studies on GE foods than GeneWatch editors would lead one to believe.
But other cases remain troubling. For example, “Were potatoes engineered to produce a lectin unsafe to eat?” The studies she cites, with respect to Pusztai’s findings, don’t accurately settle the matter whether it was the lectins or GE process that introduced damaging toxins into the small number of laboratory rats that consumed the lectin-containing potatoes. If the pro-GMO community was so concerned about the negative outcomes and publicity, why didn’t anyone reproduce the study with clearly presented, standard methodologies and proper controls?Analogously, why are there not more rigorous studies countering the possible toxic implications of Roundup Ready soybeans on reproductive outcomes, as asserted by Irina Ermakova of the Russian Academy of Sciences, whose laboratory methods were also said to lack proper controls, and whose work was not subjected to rigorous peer review? Lemaux’s treatment of allergen issues similarly suggests the need for more diverse testing of Bt corn varieties. Finally, it would appear to be a no-brainer that GE of plants as pharmaceutical delivery vehicles should avoid common food crops, in order to prevent any possible contamination and unintended entry of pharmaceuticals into the food supply chain. Even “The Grocery Manufacturers of America urged the USDA to restrict plant-made pharmaceutical production to non-food crops” (Lemaux 2012:131). Her conclusions, that “In deciding whether the crop should be grown in the field the focus should be on possible consequences of such mixing” can be taken to suggest that this focus is not yet implemented. Her final point, on global production of GE crops, also raises alarms: “The potential use of a wider range of organisms as sources of genes to introduce new traits and the creation of GE crops and foods by countries with less rigorous regulatory structures present new identification and safety assessment challenges for foods” (p.133).
Then there are the “who benefits?” and “who takes the risks?” questions. A multi-disciplinary Wisconsin case study of Healthy Grown potatoes, which use GE traits to lower needs for chemical inputs and thereby lower toxicity scores admits: “The economic advantage to the grower, packer, or other parts of the potato industry is uncertain.” The researchers assume “Transformed varieties will certainly incur license fees for seed and other potential costs.” In addition, if pest-resistant potatoes raise production through greater efficiencies, this likely would cause prices to fall, with no certainty that consumer demand would increase to make up the difference. This would decrease profitability, although one might argue, on the positive side, that reduced expenses for inputs, and reduced exposure to pesticides are pluses. (p.207) (All these points are taken from the chapter: Bussan, Alvin J., Deana Knuteson, Jed Colquhoun, Lary Binning, Shelley Jansky, Jiming Jiang, Paul D. Mitchell, Water R. Stevenson, Russell Groves, Jeff Whyman, Matt Ruark, and Keith Kelling. Case Study. Healthy Grown Potatoes and Sustainability of Wisconsin Potato Production. Pp.192-211.)
Loss of biodiversity in major food crops is also a persistent issue recognized among proponents. Whereas in the US, within less than a decade, Monsanto’s herbicide-tolerant, Roundup-Ready (RR) trait had been inserted into more than 1,100 local varieties of soybean, which had been selected by farmers and breeders over the years to “optimize yields and other product properties specific to local conditions,” such rapid GE breeding facilities are not routinely available in developing countries, where “When a transgenic trait is not available in a local variety, a farmer must switch to a generic variety in which the trait is available. This switch is likely to result in yield and other losses. Farmers trade off gains from the trait with losses from the generic variety.” Only where the proper “incentives” are available will “seed supplier … add the transgenic traits to local varieties” ; that is, “where the necessary genetic materials are available at low transaction costs and where there is sufficient technical capacity to backcross or modify local varieties at relatively low cost” (p.256) Although these conditions may be met in large producing places, such as the US, China, and India, “Concern regarding lack of technical capacity may lead to the introduction of only a few generic transgenic varieties in Africa, unless that capacity is upgraded.” Such observations are consistent with GeneWatch reports indicating pressures on seed stores to sell transgenic varieties and concerns about reductions in biodiversity. (p.256). Concerns about co-evolution of pests, including Bt-resistant insects and glyphosate-tolerant weeds are also acknowledged as management challenges that emerge in the proliferation and expansion of GE crop plants (p.257). All these points are raised in the chapter by Graff, Gregory D. and David Zilberman (2012) “Agricultural Biotechnology. Equity and Prosperity”, pp.252-266.)
Hopefully Lemaux will continue to explore and communicate new findings on the ways GE crops can be part of sustainable food systems. (Lemaux, Peggy G. (2012) Genetically Engineered Crops Can Be Part of a Sustainable Food Supply. In The Role of Biotechnology in a Sustainable Food Supply. Eds. Jennie S. Popp, Milly M. Jahn, Marty D. Matlock, and Nathan P. Kemper. Pp.122-140. New York: Cambridge University Press.) Her frustrations at being unable to commercialize products that she has developed in the lab, are chronicled in a 2014 Berkeley Science Review interview (Gadye, Levi (2014) GM to Order). This journalist’s piece identifies new breeding technologies, including CRISPR gene-editing techniques, as possible solutions, which can circumvent corporate intellectual property rights and high patent and licensing fees that keep university scientists from moving useful, targeted products to market. These innovative gene-editing techniques take GE products out of the hands of Monsanto and a few other domineering corporate conglomerates and potentially have wide applications across a range of crops. Targeted species include vegetatively propagated crops such as cassava that have proved more difficult to genetically-transform and regenerate consistently to deliver traits of interest.
But these innovative techniques continue and possibly raise the risk-monitoring concerns that currently constrain university and other scientists and technologists, whose reasoning will not automatically dispel public distrust and questionable understandings of science. High profile GE salmon and Campbell Soup’s recent decision to label all GMO ingredients should contribute to a flavorful and simmering stew for 2016.